Antibody Discovery And Engineering Scientist

Randstad Technologies Recruitment; Slough; On-site; GBP 35,000 - 65,000

Job description

Do you want to help shape the delivery of next generation antibody therapeutics? Do you have knowledge of molecular biology and microbiological methods, and a proven track record of antibody discovery or protein engineering? If so, we would love to hear from you!

We are recruiting for an Antibody Discovery and Engineering Scientist, at either Senior or Research Scientist level. This role is offered on a contract basis initially for 12 months.

This is an excellent opportunity to join a dynamic and thriving team of scientists helping to develop and validate new sequence-based and structure-based antibody design approaches. This includes elements of antibody hit identification, sequence optimisation and in silico de novo antibody design.

Responsibilities:

1. Play a key role in the discovery of therapeutic monoclonal antibodies to support our clients pipeline and help create value for patients suffering with serious disease.
2. Using cutting-edge yeast display for the discovery and optimisation of human antibodies aligned with therapeutic targets.
3. Design, construct, and perform selections using bespoke synthetic display libraries to support in silico de novo antibody discovery and optimisation projects.
4. The preparation of next generation sequencing (NGS) libraries and their analyses to support antibody discovery and engineering of lead molecules.
5. Working closely with computational and CADD scientists, co-develop and apply AI/Deep learning solutions and structure-based approaches to facilitate discovery and engineering of high-quality antibody molecules.
6. Contribute to the development and implementation of new methodologies in antibody display and engineering.
7. Work flexibly across project teams to ensure delivery of results against expected timelines.
8. Present experimental data at cross-functional meetings.

Qualifications / Experience:

1. A PhD (or equivalent) with molecular biology and protein biochemistry knowledge ideally within the antibody space.
2. Knowledge and experience in the use of in vitro display libraries for either discovery, affinity maturation, or other protein engineering, preferably to include structure or deep sequence-guided insight would be desirable.
3. Demonstrable experience of biochemical techniques for the characterisation of macromolecules such as flow-cytometry, surface plasmon resonance or Bio-layer interferometry would be beneficial.
4. Skills in informatics and other computational platforms such as molecular visualisation and next generation sequencing data analysis would be advantageous.
5. Highly motivated with excellent attention to detail and critical data analysis skills.
6. A trusted ability to deliver to deadlines.
7. Excellent communication skills.

In 2025, this site will relocate from Slough to Windlesham Surrey so applicants must be able to get to both locations.

Randstad CPE values diversity and promotes equality. No terminology in this advert is intended to discriminate against any of the protected characteristics that fall under the Equality Act 2010. We encourage and welcome applications from all sections of society and are more than happy to discuss reasonable adjustments and/or additional arrangements as required to support your application.

Candidates must be eligible to live and work in the UK.

For the purposes of the Conduct Regulations 2003, when advertising permanent vacancies we are acting as an Employment Agency, and when advertising temporary/contract vacancies we are acting as an Employment Business.