Senior Scientist Biochemistry and Structural Biology (m/f/d)

Senior Scientist Biochemistry and Structural Biology (m/f/d)

Country: Germany

Department: Research & Development

Job ID: 44487

Professional | Permanent | Full-time | Hybrid

If you’re passionate about changing lives for the better, this is the opportunity you’ve been waiting for. In Research & Development, we’re continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve. You’ll join a team of talented colleagues dedicated to developing innovative medicines that change the life of patients for the better and help us make progress towards our vision of a world free of pain. Join us today and discover the difference you can make.

What the job looks like
Each day you’ll enjoy a variety of challenges, such as:

1. Generate impactful biochemical, biophysical, and structural biology data with human relevance to support our small molecule- and genetic medicine projects.
2. Explore target mechanisms, propose and evaluate novel targets.
3. Propose internal programs and represent Biochemistry and Structural Biology in cross-disciplinary project teams.
4. Explore and supervise external collaborations with academia, biotech companies and contract research organizations in the field of Biochemistry, Biophysics and Structural Biology.
5. Ensure high quality experimentation (both internal and external), analysis, and data management.
6. Foster open and clear communication across different functions.

What you’ll bring to the table
To make the most of this role and truly thrive, you should have:

1. A PhD in biochemistry or structural biology or a closely related discipline with a minimum of 5 years’ work experience in an industrial drug discovery setting.
2. Proven ability to independently design and safely execute wet lab experiments.
3. Experience and proven track record in the development and use of biochemical assays to study different molecular target classes (e.g. ELISA assays, biomarker detection, protein purification, protein-protein or protein-ligand interactions, protein turn over, enzymatic assays, capillary-based immunoassays and automated Western blot analysis).
4. Experience in biophysical and structural biology techniques (e.g. surface plasmon resonance, microscale thermophoresis, spectral shift, differential scanning fluorimetry, dynamic light scattering, calorimetry, x-ray crystallographic analysis, cryo-electron microscopy).
5. Experience with RNA-modulating therapies (e.g. ASO, siRNA) incl. targeted delivery is an advantage.
6. A passion for investigating molecular mechanisms and exploring targets with a good understanding on how targets/pathways can be modulated in pain, neuroscience or adjacent disease areas.
7. Ability to set up novel techniques in a result-oriented manner and challenge the status quo with an open mind.
8. Pragmatic, optimistic, problem-solving attitude with natural curiosity; someone who will reach out proactively, internally and externally, to source alternative solutions.
9. Excellent mathematical skills and data analysis capabilities with a drive for data quality and high-quality documentation.
10. Excellent organizational and communication skills with a high level of team spirit.

"Are you an enthusiastic and experienced scientist with passion to design human confidence-building biochemical experiments and to learn from structural models to design better molecules? Would you like to help us to bring innovative medicines to pain patients? Then we are looking forward to your application."

Gregor Bahrenberg, the Hiring Manager

Grünenthal is a global leader in pain management and related diseases. As a science-based, fully-integrated pharmaceutical company, we have a long track record of bringing innovative treatments and state-of-the-art technologies to patients worldwide. Our purpose is to change lives for the better – and innovation is our passion. We are focusing all of our activities and efforts on working towards our vision of a world free of pain.

Grünenthal is headquartered in Aachen, Germany, and has affiliates in 27 countries across Europe, Latin America and the US. Our products are available in approx. 100 countries. In 2023, Grünenthal employed around 4,400 people and achieved revenues of € 1.8bn.