Research Fellow (OR/NBD/VP) 1.

Company description:

The National University of Singapore is the national research university of Singapore. Founded in 1905 as the Straits Settlements and the Federated Malay States Government Medical School, NUS is the oldest higher education institution in Singapore

The Signature Research Programme in Neuroscience and Behavioural Disorders (NBD), one of five Signature Research Programmes at Duke-NUS Medical School, is focused on understanding the structure and function of the nervous system, and the neural mechanisms underlying human neurological, psychiatric and ophthalmological disorders.

The Translational Neuroscience Group led by Professor Vincenzo De Paola (https://www.duke-nus.edu.sg/nbd/the-team/faculty-members/details/Detail/de-paola-vincenzo) at Duke-NUS Medical School is looking for Research Fellows/Senior Research Fellows.

The De Paola Lab at Duke-NUS aims to understand the regulation of neural network connectivity and function in the neocortex, a brain region affected in numerous developmental and degenerative diseases as well as acute injuries, which are incurable to date. To study complex genetic neuropsychiatric conditions such as Down syndrome, autism and Alzheimer's disease, we are building more advanced human experimental in vivo cellular models. We focus on the role of the synaptic life cycle (i.e. synapse formation and elimination), and on the mechanisms of axon degeneration and regeneration. We combine human iPSC models, structural and functional imaging of in vivo self-assembled human cortical circuitry (as in Real et al Science 2018, complemented with human derived microglia), with state-of-the-art molecular and computational biology skills.

We are looking for highly motivated, persistent and committed researchers with a strong interest in the wiring and dysfunction of human cortical circuits, and in how we can increase and harness their regenerative potential to transform the treatment of neurodegenerative and neuropsychiatric brain disorders. We are located in a modern building with state-of-the-art core facilities adjacent to the Singapore General Hospital, and have strong basic, translational and clinical research partnerships throughout Singapore, including the National Neuroscience Institute.

Duke-NUS offers a highly attractive remuneration package, including competitive salary and benefits comparable to the world top institutions, as well as exciting training and career advancement opportunities.

Key tasks and responsibilities

The selected candidate will perform a variety of research activities under the supervision of the Principal Investigator, including but not limited to the following: -

• Independently carry out the planning and executing of research projects.
• Conceptualise ideas and develop independent research plans which could attract research funding.
• Provide guidance and mentorship to a small research team of junior researchers, graduate and/or undergraduate students.
• Identify and develop suitable approaches for the collection and analysis of data.
• Maintain accurate and complete records of all findings, and ensure the validity and reliability of data at all times.
• Perform oral presentations and write manuscripts for publications.
• Develop contacts and research collaborations within the School and the wider community.
• Perform other related duties incidental to the work described therein.

• PhD or MD degree with at least 3 years of relevant research experience and strong first-author publication record in relevant areas.
• Experience with human stem cell neurobiology and/or mouse genetics, electrophysiology, viral vectors, stereotaxic surgery is desirable.
• Demonstrated capability of research independence.
• Have strategic thinking, management skills and experience in supervision of junior lab members.
• Possess strong interpersonal communications skills with excellent writing, oral communication and presentation skills.
• A strong team player who is open-minded, energetic, highly motivated and can work collaboratively in an interdisciplinary team and diverse workforce.

Applicants should send in a single PDF their CV, list of publications and a statement of research interests clearly linking their track record to the proposed research in our team, as well as arrange to have at least two confidential letters of reference sent by referees to this email address vincenzo.depaola@duke-nus.edu.sg. Positions will remain open until filled.

We regret that only shortlisted candidates will be notified.