Research Associate, Bioinformatics

Full-time position – SG based location

Hummingbird Bioscience is a biotherapeutics company working at the interface of artificial intelligence and human innovation to discover and develop transformative medicines for hard-to-treat diseases. Hummingbird Bioscience’s computational and systems biology technologies have generated a pipeline of innovative clinical-stage monoclonal antibodies and antibody-drug conjugates in oncology and autoimmunity. At Hummingbird Bioscience, the commitment to rigorous science, teamwork, and intellectual integrity underpins our passion to accelerate the journey of new drugs from concept to clinic.

For more information, please visit www.hummingbirdbioscience.com, and follow Hummingbird Bioscience on LinkedIn, X (formerly Twitter), and YouTube.

The Bioinformatics team at Hummingbird Bioscience is expanding to meet the challenges of drug development. Our team delivers data-driven, actionable insights through the application of computational approaches to guide strategic decisions in drug and clinical development that are already having a profound impact on the lives of patients.

We are looking for a talented and highly motivated Bioinformatics Research Associate. The ideal candidate should have a strong background in AI/ML methods for biomolecule design, experience in biological data analysis, and a passion for accelerating drug development through computational approaches.

This is a full time role based in Singapore.

• Develop AI-assisted biomolecule design methods and strategies for prioritization and selection
• Apply computational methods to predict antibody-antigen epitopes and calculate metrics such as binding distance, RMSD and binding free energy
• Implement bioinformatics pipelines for analyzing NGS experiment results, including variant calling, differential expression analysis, and clonotype reconstruction
• Perform data analysis of multi-modal pre-clinical and clinical data to support biomarker identification, MOA and strategy development
• Build containerized applications, tools and environments (Docker/singularity/Conda)
• Support the development of ETL pipelines, databases, and dashboards for clinical trial data integration
• Assist in preparing reports, results, visualizations, and delivering presentations

• Bachelor/Master’s degree in bioinformatics, computer science, data science, computational biology, or any related field
• 1-3 years of relevant experience
• Proficient in Python
• Demonstrated experience with AI tools for biomolecule design, including RFdiffusion, AlphaFold, ESM, Chai-1, and ProteinMPNN
• Experience in processing common bioinformatics formats, including FASTA, PDB, and FASTQ
• Demonstrated ability to containerize tools and environments (docker/singularity/conda)
• Expertise in using Unix operating systems and HPC job schedulers (qsub/slurm)
• Strong communication skills, collaboration, teamwork and the ability to work independently

• Familiarity with developing workflow pipelines (CWL or Nextflow)
• Interest in biomedical research, drug and clinical development
• Familiarity with AWS cloud services and concepts
• Familiarity with R programming
• Knowledge of database frameworks (SQL)
• Interest in training and mentoring interns through hands-on training experiences to effectively support project tasks
• The ability to lead multiple simultaneous projects, and to adapt to changing priorities with tight deadlines

Our fast-growing biotechnology company is committed to discovering and developing important new drugs for cancer and autoimmune diseases, and living by our values: Excellence, Determination, Teamwork, Intellectual Integrity and Audacity.

We are looking for passionate and motivated individuals committed to solving important, complex problems. We are committed to the personal and professional development of our team and offer robust learning and development programs. Hummingbird Bioscience understands the need for flexibility for our team and offers a generous paid time off program with flexibility to support employees through different life stages. We invest in our team’s health by offering competitive benefits including health and dental insurance, and a comprehensive and holistic employee assistance program. We foster a more collaborative, productive, and sociable culture with on-site lunches and snacks. Finally, we believe in creating social impact beyond our business through corporate social responsibility initiatives.

Are you ready to join us on our mission to discover and develop important new drugs for cancer and autoimmune disease? Click on ‘Apply for this Job’ to submit your application.

For further enquiries, please email us at careers@hummingbirdbio.com.