PhD Position in the development of therapies to restore disrupted circadian rhythms

PhD Position in the development of therapies to restore disrupted circadian rhythms

Do you want to contribute to top quality medical research?

Do you want to contribute to better health for all?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The doctoral student will be part of the Chronobiology research group, led by Dr. Paul Petrus, at the Department of Physiology and Pharmacology, Karolinska Institutet. The group focuses on circadian cross-tissue coordination and how disruptions to this system result in metabolic and mental morbidities. The team combines experimental and computational approaches, including transcriptomics, bioinformatics, in vitro systems and animal models, to understand the mechanisms underlying chronodisruption.

The doctoral student project and the duties of the doctoral student

The project investigates how physiology is influenced by circadian disruption and approaches to reset the system. This will be done using animal models, cell culture systems, and bioinformatics. The student will design and perform experiments, analyze large multi-organ circadian datasets, and contribute to scientific publications. The role requires strong motivation, a collaborative mindset, and an interest in chronobiology, molecular biology, and bioinformatics.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

• have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
• have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
• have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

Minimum qualifications

• A master’s degree in a relevant field such as molecular biology, biomedicine, or biotechnology
• Practical experience with laboratory techniques in cell or molecular biology
• Programming skills (e.g., R or Python)
• Experience with animal experiments
• Good communication skills in English, both written and spoken
• Experience with cell culture models
• Experience with research in chronobiology
• Strong interest in circadian biology and inter-organ communication

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

• A personal letter and a curriculum vitae
• Degree projects and previous publications, if any
• Any other documentation showing the desirable skills and personal qualities described above
• Documents certifying your general eligibility (see A above)
• Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

• Documented subject knowledge of relevance to the area of research
• Analytical skill
• Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Want to make a difference? Join us and contribute to better health for all

Type of employment: PhD placement

Contract type: Full time

First day of employment: Upon agreement

Salary: Monthly salary

Number of positions: 1

Full-time equivalent: 100

City: Stockholm

Country: Sweden

Reference number:

Contact:

• Paul Peterus, group leader FyFa, paul.petrus@ki.se