Post doctoral Research Scientist

The Buffa Lab is seeking a highly motivated postdoctoral scientist to work on a project entitled “Multi-omics characterization of the hypoxia response to dissect mechanisms of cancer progression and metastasis”. The laboratory uses systems biology approaches to understand how cancer evolves and responds to treatment, and how the tumor microenvironment affects this process. In our previous studies, we have extensively characterized the transcriptional response to hypoxia, in bulk and single cells, in multiple cancer types, but the role of epigenetic changes remains unexplored. This project aims to understand the reprogramming of the cells exposed to early and chronic hypoxia in multiple experimental models, with a particular focus on epigenetics and single cell sequencing. The project will involve in vitro cell culture, organoids and next generation sequencing approaches.

Profile Description

The ideal candidate will possess robust communication skills, self-motivation, and the ability to work autonomously. Additionally, they should be capable of fostering collaboration and constructive contributions within IFOM's scientific environment.

1. Proficiency in standard biochemical/molecular/cell biology techniques;
2. Demonstrable knowledge and experience of current omics assays;
3. Publications in internationally recognized journals;
4. Presentations of scientific findings at conferences, seminars or other relevant meetings;
5. Ability to work independently and as part of a team;
6. Ability to take the lead and manage small research projects when required;
7. Attention to detail and the ability to keep accurate and ordered experimental data;
8. Reliability and flexibility.

Desirable

1. Multiple first-author publication in internationally recognised journals;
2. Having obtained previous grant funding;
3. Experience in genomics, transcriptomics or proteomics;
4. Experience with biochemical techniques, shRNA, CRISPR.

Language skills

Excellent oral and written English.

Educational experience

PhD in molecular or cellular biology or a related field.

We offer

A dynamic, international scientific environment set within IFOM. The institute hosts a range of state-of-the-art core facilities, seminar series, and social programming. We are located in the vibrant city of Milan, Italy and offer a range of benefits to employees, including an international Welcome Office, flextime, Guest house inside the Campus, Agreements with discounts for Gym, Pharmacy, Psychology service and various shops around Ifom area. Bar and canteen inside the campus & lunch benefit, Company Nursery, Medical Service, Caf service- tax declaration.

Application Process

Interested candidates should send a motivation letter, CV, and contact information for at least two references to: francesca.buffa@ifom.eu