Extracellular vesicles isolated from mesenchymal stromal cells as a "Drug delivery system" for [...]

Organisation/Company: Università degli Studi di Torino

Research Field: Medical sciences

Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3)

Country: Italy

Application Deadline: 27 Jan 2025 - 13:00 (UTC)

Type of Contract: To be defined

Job Status: Not Applicable

Is the job funded through the EU Research Framework Programme? Not funded by a EU programme

Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Sarcomas are rare tumours accounting for 10% of all paediatric tumours, but still very aggressive for children and adolescents. Extracellular Vesicles (EVs) isolated from Mesenchymal Stromal Cell (MSC) secretome represents a new model for drug delivery, as it allows a controlled and selective release towards the tumour, increasing the biological effect, but limiting toxicity.

Recent studies at the Stem Cell Transplantation Laboratory have demonstrated that the EVs isolated from MSC secretome, loaded with chemotherapy drugs, have a cytotoxic action on osteosarcoma lines, and a new drug delivery system (DDS) approach could be used. For clinical application, it is necessary to characterize the EVs loaded with chemotherapeutic drugs, conduct in vivo studies on murine and canine osteosarcoma models, and propose a phase I study for the treatment of paediatric osteosarcoma patients.

Eligibility of fellows:

Country/ies of residence: All

Nationality/ies: All