Unlocking the structure and function of the mitochondrial transporter FLVCR1

Organisation/Company: Università degli Studi di Torino

Research Field: Biological sciences

Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3)

Country: Italy

Application Deadline: 27 Jan 2025 - 13:00 (UTC)

Type of Contract: To be defined

Job Status: Not Applicable

Is the job funded through the EU Research Framework Programme? Not funded by a EU programme

Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Feline Leukemia Virus subgroup C Receptor 1 (FLVCR1) is an essential transporter whose mutations are responsible for rare neurodegenerative disorders, including Posterior Column Ataxia and Retinitis Pigmentosa (PCARP), Hereditary Sensory and Autonomic Neuropathy (HSAN), and congenital hydrocephalus (CH). We recently demonstrated that the full-length isoform encoded by the FLVCR1 gene, FLVCR1a, interacts with the IP3R3-VDAC1-GRP75 complex. This complex localizes at the mitochondria-associated membranes (MAMs) that are involved in several processes including calcium flux from the endoplasmic reticulum (ER) to mitochondria. This project will focus on another isoform encoded by the FLVCR1 gene, named FLVCR1b, previously shown to localize in mitochondria. Specifically, the project aims to investigate in further detail the function of FLVCR1b. The results of this project will have important implications for understanding the pathogenesis of FLVCR1-related disorders.

Eligibility of fellows:

Country/ies of residence: All

Nationality/ies: