Technologist position as Senior Bioinformatician - 3D Chromatin and non-coding RNAs - (25000012)

3D Chromatin Conformation and RNA Genomics

Organisation/Company: ISTITUTO ITALIANO DI TECNOLOGIA

Department: 3D Chromatin Conformation and RNA Genomics

Research Field: Computer science » Informatics, Biological sciences » Biology

Researcher Profile: Recognised Researcher (R2)

Positions: Postdoc Positions

Country: Italy

Application Deadline: 30 Mar 2025 - 09:55 (Europe/Rome)

Type of Contract: Temporary

Job Status: Full-time

Hours Per Week: 40

Is the job funded through the EU Research Framework Programme? Not funded by a EU programme

Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Project: “Exploring the role of non-coding RNAs in 3D chromatin Hubs” – Acronym: 3D-Hubs – Grant Agreement number: FIS-2023-02410 – CUP: J53C24004180001

Contract: Fixed-term contract, full time

Duration: up to 3 years

THE ROLE

You will be working in a multicultural and multi-disciplinary group, where junior and senior scientists collaborate, each with their expertise, to carry out a scientific activity with a shared research goal.

The “3D Chromatin Conformation and RNA Genomics” Research Unit is coordinated by Dr. Dafne Campigli Di Giammartino and aims at understanding how non-coding elements (DNA/RNA) and their epigenetic/epitranscriptomic modifications regulate 3D genome architecture and gene expression. To address this question, we use cutting-edge chromatin conformation assays (e.g. Hi-C, Hi-ChIP etc.) in conjunction with other -omics techniques (e.g. ChIPseq, RNA-seq etc.) and in combination with CRISPR-based genetic and epigenetic engineering tools in mouse stem cells as well as in human tumor stem cells.

Moreover, as a member of the FANTOM6 consortium, bioinformaticians in our lab have the opportunity to attend and actively participate in this international consortium with ample opportunities for collaborations within the IIT and with extramural institutions to implement new workflows and pipelines.

As a key member of our research team, you will:

• Analyze in-house produced NGS data (ChIP-seq, RNA-seq, Hi-C, HiChIP, Micro-C, RADICL-seq etc.) and integrate with publicly available datasets.
• Engage with our bioinformatic collaborators to optimize analysis workflows and share expertise.
• Support experimental biologists by integrating multi-omic analyses to identify optimal targets for functional validation.
• Interpret results of the analyzed datasets to create figures for grant proposals (e.g. Horizon EU funds, AIRC etc.), for internal as well as external oral presentations, and publications in peer-reviewed journals.

ESSENTIAL REQUIREMENTS

• PhD in Bioinformatics/Computational Biology/Computer Science or 5 years hands-on experience in analysis of NGS datasets.
• High proficiency level in programming using R and/or Python.
• A solid understanding of statistical methodologies commonly applied to biological data analysis.
• Proven ability to analyze next-generation sequencing data such as RNA-seq, ChIPseq etc.
• Ability to work and think independently, and collaboratively in a highly interdisciplinary environment, with a pro-active attitude.
• Good publication record.
• Good command of spoken and written English.

ADDITIONAL SKILLS

• Experience in analysis of chromatin conformation data such as Hi-C is not mandatory but will be considered a plus.
• Familiarity with analysis of long-read Nanopore data will be considered a plus.

COMPENSATION PACKAGE

• A yearly gross salary ranging between 45K and 55K, which may include a bonus option depending on your role and contract.
• Flexible working time.
• Wide range of staff discounts.
• Candidates from abroad or Italian citizens who have carried scientific research activity permanently abroad and meet specific requirements may be entitled to a deduction from taxable income of up to 90% from 6 to 13 years.

Please submit your application using the online form and including:

• Your CV
• Contact info of 2-3 referees
• A 1 page Cover letter specifying your skills and motivations.