Development of new therapeutic approaches for the management of chronic diseases, oncological d[...]

Organisation/Company: Università degli Studi di Urbino Carlo Bo – DISB

Research Field: Biological sciences

Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3)

Country: Italy

Application Deadline: 18 Jan 2025 - 23:59 (UTC)

Type of Contract: To be defined

Job Status: Not Applicable

Is the job funded through the EU Research Framework Programme? Not funded by a EU programme

Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The project involves designing an oral release system of encapsulated enzymes that reach the intestine and degrade specific toxic metabolites before they are absorbed into the systemic circulation. The encapsulation allows the enzymes to withstand the acidic environment of the stomach and to activate only in the intestine, transforming toxic compounds into harmless molecules.

Functioning: The gastro-resistant capsules contain enzymes selected for specific diseases, such as those that degrade certain toxic amino acids or sugars. In the intestinal environment, the capsule dissolves, allowing the entrapped enzymes to act in a targeted and safe manner.

Advantages:

• Reduction of systemic toxicity by preventing the absorption of harmful molecules.
• Non-invasive alternative to conventional drugs.
• Customizable for different types of rare diseases and specific metabolic needs.