Senior Scientist, Protein Characterization, Mass Spectrometry

Johnson & Johnson; Malvern; On-site; GBP 45,000 - 85,000; Full time

Job description

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function: Discovery & Pre-Clinical/Clinical Development

Job Sub Function: Biotherapeutics R&D

Job Category: Scientific/Technology

All Job Posting Locations: Malvern, Pennsylvania, United States of America

Job Description:

About Innovative Medicine:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Senior Scientist, Protein Characterization, Mass Spectrometry to be in Malvern, PA

Purpose:

The Therapeutics Discovery & Supply-Analytical Development (TDS-AD) is recruiting for a Senior Scientist located in Malvern, PA. We discover and develop creative large molecule solutions to address significant unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases.

The Analytical Development organization is continuing to build key scientific expertise in protein and vaccine characterization, and primary structure elucidation! We need a hardworking scientist willing to bring their expertise to exciting efforts in novel areas of protein characterization.

You will join the Primary Structure team within the Characterization group in the TDS-AD department to conduct product characterization and process development activities.

You will be responsible for:

• Operating state-of-the-art LC and MS instrumentation
• Learning and applying different software packages for LCMS/protein analysis
• Performing LCMS-based quantitation of post-translational modifications
• Designing and implementing peptide mapping / MS experiments on monoclonal antibodies and recombinant proteins to assess sequence coverage and sites of modification
• Participating in IND, IMPD, BLA, and other regulatory filings
• Developing test methods, providing documentation and writing scientific reports.
• Conducting testing to support analytical development, manufacturing process development, process validations, and manufacturing investigations
• Leading or facilitating technical discussions and participating in cross-functional teams at project-related meetings

Qualifications / Requirements:

Education:

• A Ph.D. in chemistry, biochemistry or a related field is required

Required:

• Hands-on experience with LC-MS is required

Preferred:

• Proficiency at running and troubleshooting assays is preferred
• Experience maintaining high quality documentation, analyzing and accurately interpreting data, and preparing reports, and SOPs is preferred
• Strong written and verbal communication and excellent interpersonal skills are preferred
• An understanding and experience in the application of various GXP concepts is preferred