Senior Principal Scientist, In Vitro Pharmacology

Job Description

About Us

We are a growing biotech startup pioneering the development of weight loss therapeutics with the potential to revolutionize the treatment of obesity. Our team is passionate about making a real difference in people's lives, and we're committed to building a collaborative, fast-paced, and fun work environment.

Role Summary

The Scientist will lead a core in vitro research activities of the drug development team, leveraging technical expertise in assay development and optimization to support the discovery and characterisation of novel drug candidates.

The Impact you will have at Metsera

Under the guidance of the Vice President of R&D, the applicant's main role will include:

• Developing an in vitro strategy to support the R&D activities of Metsera
• Leading in-house experimental design and execution
• Leading the outsourcing of in vitro experiments
• Optimising and executing cell-based screening assays to monitor receptor-ligand and protein-protein interactions
• Training and managing other laboratory members
• Performing ELISAs or other biological assays to support the research outcomes of in vivo studies
• Maintaining accurate written and computer-based records for all studies
• Analysing large datasets and generating research reports
• From time to time, other duties may include:
• Undertaking any necessary training and/or development
• Carrying out such other duties as necessary to assist in the smooth and efficient operation of the laboratory and facilities, including cleaning and maintenance

What you bring to Metsera

• PhD degree in related scientific field and 3+ years of experience or have equivalent academic, industrial, or commercial experience
• Demonstrated experience solving program challenges by leveraging strong scientific fundamentals in related subject areas including in vitro pharmacology, ex vivo pharmacology, and experimental design.
• Knowledge of a breadth of techniques for exploring GPCR pharmacology, including biosensor or reporter assays
• Proven track record for cell-based assay development and optimisation
• Proven ability to lead program development teams using project management skills
• Strong leadership/interpersonal skills and motivation to work in a team environment with cross-functional interactions are essential
• Advanced computation, data analysis, and visualization skills
• Excellent verbal and written communication skills
• Enterprise mindset, with decision making driven by an appropriately balanced consideration of driving the business and developing staff
• A co-operative, flexible attitude towards work
• Able to self-prioritise and manage own work with minimal supervision
• A co-operative, flexible attitude towards work with ambition for professional and personal development

Preferred Qualifications:

• Experience in partnering with pharmacology SMEs and academics and collaborating with partner functions in chemistry and/or biologics.
• Working in a GLP environment
• Awareness of emerging obesity pharmacotherapies
• Previous experience of working with biologics

Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metsera. Agencies and independent recruiters must be approved as a vendor by Metsera's Human Strategy team. To protect the interests of all parties, Metsera will not accept unsolicited resumes, profiles, or biographies. Any unsolicited submissions will be considered referrals and become the property of Metsera. Contacting hiring managers, executives, or any member of the Human Strategy team will not influence vendor approval and is strongly discouraged. Repeated outreach may impact future consideration.