Senior Laboratory Research Scientist – Santos Lab

Short summary

The Quantitative Stem Cell Biology lab, headed by Dr Silvia Santos, is seeking a Senior Laboratory Research Scientist (SLRS). The successful candidate will investigate spatio-temporal control of cell division and cell cycle remodelling during cellular differentiation using 2D and 3D stem cell-based models of human gastrulation. The postholder will drive a research project and contribute to collaborative projects within the lab. The postholder will benefit from excellent mentorship and training.

The research group

The Quantitative Stem Cell Biology lab, headed by Dr Silvia Santos, was established in 2018 at the Francis Crick Institute. The lab’s primary focus is understanding cell decision-making. Current areas of research include understanding regulatory mechanisms regulating cell fate specification, cell cycle remodeling during cellular differentiation, and the interplay between metabolism, cell cycle, and cell fate. There is a strong focus on single-cell analysis and advanced live-cell imaging. The lab uses a variety of model systems: mouse and human embryonic stem cells (ESC), 3D organoid models of mouse and human development, and mouse embryos.

The team is multi-disciplinary, diverse, and currently composed of three PhD students, two post-doctoral fellows, and one principal laboratory research scientist. The Santos lab promotes independent and creative thinking, and all members are committed to providing excellent training and mentorship.

Key Responsibilities

• Lead specific research project under the Group Leader’s supervision
• Participate in collaborative projects
• Attend and participate in group meetings and key Crick seminars
• Keep accurate records of all work carried out
• Train more junior colleagues when appropriate
• Contribute to the preparation of scientific manuscripts
• Contribute to the lab hESC feeding rota
• Contribute to the collegial, positive, and motivating lab atmosphere

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose, and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London, and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under one roof in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it to the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

If you are interested in applying for this role, please apply via the 'Apply' button.

All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

From £39,950 per annum, with benefits, subject to skills and experience.