Salary for this Role:
£39,950 - £45,275, subject to skills and experience, with benefits.
Job Title:
Senior Laboratory Research Scientist - Human Models
Reports to:
Daria Paruzina
Closing Date:
03/Jan/2025 23.59 GMT
Job Description:
Senior Laboratory Research Scientist - Human Models Core
Reports to: Head of Lab Operations (HBF)
This is a full-time, permanent position on Crick terms and conditions of employment.
Overview
The Human Models Core (HMC) is an integral part of the Human Biology Facility. HMC comprises of scientific and technical staff from the Francis Crick Institute who provide a service and support to all researchers. With close links to the Human Biology Governance Team and external partners, the HMC provides a comprehensive range of services and support for human models research. Within the HMC, there are 4 distinct core units: viral vectors, human embryo and stem cell unit (HESCU), human cell engineering, and primary models.
The area of pluripotent stem cell research is a dynamic field with a broad scope of applications due to the ability of the cells to differentiate down lineages representative of all three germ layers. Apart from the potential clinical application of human pluripotent stem cells (PSC) in the field of cell therapies, the use of these cells is well established in the area of assay development, modelling of developmental pathways, and disease modelling. The utilisation of these applications coupled with the use of gene editing tools such as CRISPR makes this type of biological system ideal to study the effects of gene knockout or gene modification.
Project summary
HESCU is involved in developing key models for human disease by reprogramming somatic cells into PSC lines and assisting with downstream applications like gene editing or differentiation.
HESCU provides and maintains a well-equipped laboratory space and as a communal lab space, facilitates interaction between the groups working with human models, pluripotent stem cells, and gene editing. The Lab aims at fostering collaborations, being a knowledge hub, and sharing protocols between the scientific groups who use the facility. We currently work with users to provide support and promote best practices in the areas of growing pluripotent stem cells, differentiation, characterisation, banking, and method development.
We are looking for a motivated, collaborative scientist to work with HESCU/HMC staff, other STP scientists, and the users to standardise reprogramming, QC and banking of PSC lines.
Key responsibilities
These include but are not limited to:
Key experience and competencies
The post holder should embody and demonstrate our core Crick values: bold, open, and collegial, in addition to the following:
Essential Qualifications, experience and competencies:
Desirable Qualifications, experience and competencies:
Please note, the advert may be taken down before the closing date if a suitable candidate is found; therefore, we would suggest that you apply for this role as soon as possible.
Find out what benefits the Crick has to offer:
For more information on our great pay and benefits package, please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits
Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment, and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies, and practices.
Read more on our website:https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion