Scientist/Senior Scientist - Protein Science and Structural Biology

Background

Sygnature Discovery is a world-leading integrated drug discovery Contract Research Organisation based in the UK and Canada with its headquarters in Nottingham and additional facilities in Alderley Park, Macclesfield, Glasgow, Montreal and Quebec City. Its staff of over 1,000, which includes 900 scientists, partners with global pharma, biotech and NFP organisations.

Since 2004, Sygnature Discovery has delivered over 40 novel pre-clinical and 22 clinical compounds, with its scientists named on over 170 patents. Therapeutic areas of expertise include oncology, inflammation and immunology, neuroscience, metabolic diseases, infectious diseases, fibrotic diseases and more. To find out more, please visit www.sygnaturediscovery.com.

About the role

Sygnature Discovery provides Protein Science Contract Research services to clients globally. These include the engineering of tailored proteins of all classes and type for a variety of end uses that includes biochemical screening, biophysics, diagnostics and biologics drug discovery. We also have a group of scientists who undertake structural studies using X-ray crystallography, CryoEM and protein NMR. Our passion is to provide clients with the protein tools and information they need to undertake their work.

Due to further expansion, an exciting opportunity has arisen for a Scientist or Senior Scientist with experience and enthusiasm for protein engineering, protein expression and purification to join our team. The position will be located at our Protein Science site in Macclesfield, Cheshire.

Main Duties and Responsibilities:

• Design DNA constructs to express proteins of interest in a suitable form for client’s needs.
• Design and execute purification strategies at various scales to produce proteins to meet client requirements.
• Execute standard and bespoke analytical packages to ensure proteins are fit for purpose.
• Capture experimental data in an appropriate format and present back to clients.
• Work flexibly as part of the wider team to maintain the necessary reagents and equipment to ensure continuous delivery.
• Contribute to the writing of work proposals for clients.

Candidate Requirements:

• As a minimum you will have a BSc/MSc in Biochemistry or a related discipline.
• At the Senior scientist level, you must have several years’ experience in drug discovery and/or a PhD and/or postdoctoral experience.
• Successful project delivery will be achieved through own individual experimental work and by working flexibly with colleagues. Good communication and team working skills are therefore essential.
• You must be able to demonstrate good problem-solving skills and in some of the techniques involved in protein expression, purification and analysis including structural biology.
• Importantly, you should show the enthusiasm and self-motivation required to develop your scientific skills and knowledge further.

Benefits

Here at Sygnature Discovery, we take pride in offering an excellent training and benefits package. As a valued employee, you will be entitled to:

• 25 days annual leave (rising with service) plus bank holidays, and buy/sell scheme
• Private Medical Insurance
• Life Insurance
• Employee Assistance Programme and mental health first aiders
• Enhanced Family Friendly Policies
• Sygnature Group Pension Scheme
• 1 paid volunteer day per year
• A host of flexible benefits to support your wellbeing and lifestyle

Why Sygnature Discovery

At Sygnature Discovery, we embody excellence in everything we do. From pioneering research to ground-breaking discoveries, we set the standard for scientific innovation. But it's collaboration that truly defines us. Across continents and disciplines, we unite to solve complex challenges, driven by a shared passion for improving lives worldwide.

We understand the importance of creating a work environment that empowers you to thrive. That’s why we have fostered a culture of collaboration and support, providing pathways for both professional and personal development. This includes a diverse range of bespoke training and development designed to accelerate both your personal and career growth.

We are committed to fostering diversity and inclusion throughout our organisation. We encourage applications from individuals of all backgrounds, ethnicity, gender identity, sexual orientation, disability, neurodiversity, age, family or parental status, beliefs, nationalities and religions. We strive to cultivate an inclusive environment where all our colleagues feel empowered to bring their true selves to work.

If you’re interested in joining a company that places people at the heart of its business, please submit your application as soon as possible as we will be interviewing on an ongoing basis.

If you have any questions or need further information, please contact the Talent Acquisition team at careers@sygnaturediscovery.com. Please do not submit your application to this email address.

For more information on life at Sygnature Discovery, visit www.sygnaturediscovery.com/careers