Research Associate in iPSC and Neurodegeneration

Job id: 099445. Salary: £44,105 - £46,421 per annum, including London Weighting Allowance.

Posted: 08 November 2024. Closing date: 01 December 2024.

Business unit: IoPPN. Department: Basic & Clinical Neuroscience.

Contact details: Dr Caroline Vance. Caroline.vance@kcl.ac.uk

Location: Denmark Hill Campus. Category: Research.

About us

The post is based within two research groups at the Maurice Wohl Clinical Neuroscience Institute on the Denmark Hill Campus within the Department of Basic and Clinical Neuroscience (BCN). This is part of the Institute of Psychiatry, Psychology and Neuroscience at King’s College London. Additionally, one research group is placed within the UK Dementia Research Institute (DRI) centre that is embedded within the BCN Department.

About the role

This is an exciting opportunity to join the labs of Dr Caroline Vance and Dr Marc-David Ruepp to work on an MND Association funded project to explore the role of the ALS-related protein FUS and its function at the synapse. Led by Caroline Vance, this project will utilise a range of iPSC models to investigate how mutations and physiological aspects of FUS itself affect synaptic vesicle biology and synaptic maintenance. You will join a multidisciplinary team on the Denmark Hill Campus with a leading role in:

1. Designing and performing experiments
2. Developing technical advances
3. Performing data analysis
4. Presenting the results internally as well as externally
5. Writing up manuscripts to be submitted to peer-review journals

Post holders will also be given opportunities to work closely with a broad range of other scientists across the department.

This is a full-time post (35 hours per week), and you will be offered a fixed term contract until 30th September 2027.

About you

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

• PhD in Neuroscience or related discipline (or pending results)
• Experience in iPSC culture
• In-depth knowledge of cell biology
• Experience in neuronal differentiation
• Experience in neuronal phenotyping
• Practical experience in a broad range of standard laboratory techniques including light microscopy and molecular biology (e.g. immunofluorescence, cloning, qPCR, cell culture)
• Excellent written communication skills and the ability to write clearly and succinctly for publication

Desirable criteria

• Knowledge of ALS and/or other neurodegenerative diseases
• Understanding synaptic biology
• Experience in high-throughput microscopy
• Experience working with primary cells and tissues
• Experience in genome editing