Research Assistant/Associate - Bioinformatics

Salary:

Research Assistant: £32,296 to £33,882 per annum

Research Associate: £34,866 to £45,163 per annum

Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.

Closing Date: 5 January 2024

The Role

Are you a bioinformatician / data scientist with a passion for single cell genomics? Are you interested in joining a vibrant multi-disciplinary team working to understand how mitochondrial DNA mutations affect people in different ways?

We are looking for a motivated bioinformatician to join our dynamic research team, backed by significant funding from a recently awarded Wellcome Career Development Award. This is an exciting opportunity to collaborate with computational and wet-lab scientists at the forefront of pioneering research from the very start of a project. Our goal is to determine how the nuclear and mitochondrial genomes interact in mitochondrial DNA disease. You will harness the power of large-scale single-cell genomics to address a fundamental question in the field of mitochondrial genomics - why do people who carry the same mitochondrial DNA mutation have such different disease outcomes?

We are seeking candidates with a PhD or equivalent experience in bioinformatics, computational biology or related areas with experience of working with large scale genomic data. For candidates without a PhD, we offer the opportunity to undertake PhD training as part of the role.

In this role, you will be based at our Newcastle Upon Tyne campus, which has fantastic transport links and state of the art facilities. You will join the world-class, multidisciplinary Newcastle Mitochondrial Research Group, renowned for our extensive experience in characterising mitochondrial function in both health and disease. The group also includes a vibrant Young Scientists Group. Our researchers work in close collaboration with NHS clinical activities, bridging basic and translational science to advance the understanding of mitochondrial biology to develop new therapies for patients and families.

The position is a fixed term, full-time post and is available for a duration of 3.5 years in the first instance, starting as soon as possible, ending on 30.06.2028.

We recognise and support diverse personal circumstances and are open to discuss flexible working arrangements.

To apply for the position, we'll need your CV and a personal statement outlining how you are suitable for the role using evidence to highlight how you meet the essential criteria in the knowledge, skills and experience as listed in the job description.

Please focus your cover letter on the following key areas, outlining your ability and/or experience with:

• Designing and implementing pipelines for analysing large-scale, single-cell genomic datasets
• Supporting the development and implementation of bioinformatic pipelines for analysing multiomic datasets
• Contributing to and advising on experimental design, analysis and interpretation of results across project teams
• Collaborating regularly with the Principal Investigator, team members, and external partners to ensure high-quality research and the timely achievement of project goals

Key Accountabilities

• Design and implement pipelines for analysing large-scale, single-cell genomic datasets
• Support the development and implementation of bioinformatic pipelines for analysing large-scale multiomic datasets
• Contribute to and advise on experimental design, analysis and interpretation of results across the project team
• Although working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value'
• Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements
• Determine appropriate methodologies for research, with advice and support where required
• Contribute to grant applications submitted by others and in time develop own research objectives and proposals for funding
• Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids
• Assess research findings for the need/scope for further investigations
• Contribute to the writing up of their research for publication and dissemination, either through seminar and conference presentations or through publications
• Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
• May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants
• Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute.
• May contribute to events celebrating the public engagement of science/social sciences/humanities
• Develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment

The Person

Knowledge, Skills and Experience

• Experience of working within a Unix/Linux HPC or cloud computing environment
• Proficiency in programming (e.g. using Linux/Python and R), command-line applications, and programming standards such as version control
• High level analytical ability with attention to detail
• Experience of analysing and integrating single cell genomic datasets
• Ability to work well as part of a team and rapidly acquire new skills
• Detailed subject knowledge in the area of bioinformatics
• Likelihood of advanced skills directly related to the research projects
• High level of analytical and problem-solving capability
• Ability to communicate complex information with clarity and to encourage the commitment of others
• Experience of research with clear transferable skills and some experience or awareness of the research environment
• Presentations at conferences and/or high-quality publications

Desirable

• Familiarity with containerisation (e.g., Docker or Singularity) of informatic pipelines/workflows
• Experience accessing and utilising external, publicly available datasets (e.g., Genomics England, UKBioBank, EBI)
• Experience in integrative omics methodologies
• Understanding of the application of statistical methods to omics studies
• Experience of contributing to and advising on experimental design, analysis and interpretation of results across project teams

Attributes and Behaviour

• Excellent interpersonal skills including the ability to communicate clearly and concisely in writing and verbally
• Excellent organisational and time management skills
• An ability to work to deadlines, organise own workload and work independently
• Attention to detail
• A positive and supportive attitude; ability to work flexibly and cooperatively with others

Qualifications

• Good honours degree (or equivalent) with some subject knowledge in the relevant area (Research Assistant)
• A PhD in the research area required (Research Associate)

Newcastle University is a global University where everyone is treated with dignity and respect. We are committed to being a fully inclusive university which actively recruits, supports and retains colleagues from all sectors of society. We value diversity as well as celebrate, support and thrive on the contributions of all of our employees and the communities they represent. We are proud to be an equal opportunities employer and encourage applications from individuals who can complement our existing teams, we believe that success is built on having teams whose backgrounds and experiences reflect the diversity of our university and student population.