Postdoctoral Researcher

Findauniversity Ltd.; United Kingdom; On-site; GBP 36,000 - 40,000; Full time

Job description

£36,720 to £39,750 per annum depending on qualifications and experience.

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Howard Group at the John Innes Centre, working on cutting-edge science in the field of Computational and Systems Biology.

About the John Innes Centre:

The John Innes Centre is an independent, international centre of excellence in plant and microbial sciences. We nurture a creative, curiosity-led approach to answering fundamental questions in bioscience, and translate that knowledge into societal benefits. Our strategic vision, Healthy Plants, Healthy People, Healthy Planet, sets out our ambitious long-term goals for the game changing impact of our science globally.

Our employees enjoy access to state-of-the-art technology and a diverse range of specialist training opportunities, including support for leadership and management.

About the Howard Group:

The Howard group combines simple, predictive mathematical and biophysical modelling with long-lasting experimental collaborations to dissect biological mechanisms too complex to unravel by experiments alone. In many cases we are able to rationalise complex biological dynamics into simple underlying mechanisms, with few components and interactions.

Our approach is highly interdisciplinary and relies heavily on the techniques of statistical physics and applied mathematics, as well as on close collaboration with experimental groups. At present there are two main research areas in the group: probing how epigenetic memory states are set up and then stably maintained, and understanding patterning dynamics in sub-cellular biological systems. For epigenetics, we work on both histone modification memory systems, particularly the Polycomb silencing system, as well as on DNA methylation. For patterning, the main application at present is to the dynamics of crossover positioning in meiosis.

The group regularly publishes in the most prominent multidisciplinary journals, with recent papers in Nature, Science, Cell Systems, eLife, Molecular Cell and PNAS. Several previous members of the Howard group now hold independent faculty positions of their own, including in Warwick, Glasgow, Sydney, Amsterdam and Munich.

The role:

The main purpose of the position is to develop predictive computational models of epigenetic dynamics, collaborating particularly with the experimental group of Prof Rob Klose in the Dept of Biochemistry, Oxford University. The models will enhance our understanding of how the Polycomb system silences gene expression and how such a silenced memory state can be stably maintained through many cell cycles. The position is funded by Wellcome and would suit an individual with a high degree of independence and vision, able to advance the project independently. The successful candidate will have a rare opportunity to work on fundamental biological processes in a truly interdisciplinary environment, with seamless collaboration with a leading experimental group.

The ideal candidate:

The ideal candidate will possess (or soon complete) a PhD in Theoretical Physics, Bio-Mathematics or Computational Biology. They will possess a strong interest in biological problems and have achieved demonstrable scientific success in previous roles. Prior experience of biological modelling is desirable but not essential.

Additional information:

Candidates are required to submit a covering letter along with their CV as part of their application. Interviews will be held on 5 June 2025.

For further information and details of how to apply, please visit our website http://jobs.jic.ac.uk or contact the Human Resources team on 01603 450814 or [emailprotected] quoting reference 1004880. This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. Where the successful applicant requires a visa, we will fund the costs for their visa and the Immigration Health Surcharge. Please contact the Human Resources Team if you have any questions regarding your application or visa options.

We are an equal opportunities employer, actively supporting inclusivity and diversity. As a Disability Confident organisation, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. We are proud to hold a prestigious Gold Athena SWAN award in recognition of our inclusive culture, commitment and good practices towards advancing of gender equality. We offer an exciting, stimulating, diverse research environment and actively promote a family friendly workplace. The Institute is also a member of Stonewall’s Diversity Champions programme.

The John Innes Centre is a registered charity (No. 223852) grant-aided by the Biotechnology and Biological Sciences Research Council.