Postdoctoral Project Research Scientist – [C Swanton] Cancer Evolution and Genome Instability L[...]

Postdoctoral Project Research Scientist – [C Swanton] Cancer Evolution and Genome Instability Laboratory, London

Client: The Francis Crick Institute

Location: London, United Kingdom

Job Category: Other

EU work permit required: Yes

Job Reference: f8e8e6a02fac

Job Views: 7

Posted: 20.02.2025

Expiry Date: 06.04.2025

Job Description:

Job title: Postdoctoral Project Research Scientist – [C Swanton] Cancer Evolution and Genome Instability Laboratory

Details of the role: This is a full-time, 1 year fixed term position. Working pattern Monday - Friday

Salary: From £43,210 with benefits, subject to skills and experience

Applications close on: 21/02/25

About us…

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture.

About the role…

Lung cancer remains one of the most pressing public health concerns worldwide, demanding innovative research to address its complexities and challenges. This project seeks to advance our understanding of immunogenic mutations—genomic alterations within cancer cells that result in the production of tumor-specific antigens (neoantigens). Predicting neoantigens in lung cancer involves computational modelling to analyse somatic mutation data, along with transcriptomic and proteomic profiles, to forecast which mutations could produce immunogenic peptides capable of being presented on major histocompatibility complex (MHC) molecules.

To this end, we are seeking applications from candidates with a creative approach to research with computational competencies to work in a lab with an enviable reputation of producing papers of the highest quality.

What you will be doing…

1. Work on a European project, within the multi-disciplinary team of clinicians, bioinformaticians and bench scientists in the Swanton lab, and collaborating with groups at the Francis Crick Institute and beyond, including academic and industry partners.
2. Drive the project forward using relevant computational approaches.
3. Keep up to date with the relevant literature in the field of cancer biology and machine learning.
4. Attend and report on research results at regular group meetings.
5. Contribute to the dissemination of scientific results by means of writing papers for publication and presenting orally and in poster form at national and international meetings.

About you…

You will bring…

1. PhD in cancer biology / computational biology or other relevant discipline.
2. Good knowledge and experience in at least one of the following: cancer biology / cancer immunology / genomics.
3. Technical qualifications: expertise in common programming languages such as R or Python.
4. Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals.

About Working at the Crick…

At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences.

What will you receive?

At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:

• Visas: Applicants for this role will be eligible for sponsorship to work in the UK.
• Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.
• Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
• Health & Well-being: 24/7 GP consultation services, occupational health services, and mental health support programs.
• Work-Life Balance: Back-up care for dependents, childcare support allowance, and annual leave purchase options.
• Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts.
• Development & Recognition: Comprehensive training, mentoring, and a pay structure with performance-linked progression.

We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status.