Laboratory Technician

Bicycle Therapeutics (NASDAQ: BCYC) is a clinical-stage biopharmaceutical company developing a novel class of medicines. Our pipeline includes Bicycle Toxin Conjugates as well as fully synthetic Bicycle systemic immune cell agonists and Bicycle tumor-targeted immune cell agonists (Bicycle TICAs) focused on oncology indications with high unmet medical need. Bicycle is headquartered in Cambridge, UK, and our US operations run out of Lexington, MA.

Culture is key and all Bicycle employees actively embrace and role model our company values:

• We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.
• We are Dedicated to our Mission. You can’t change the world if you don’t have determination.
• We are One Team. We only succeed when we work together.

The Laboratory Technician plays a key role in the expansion of Bicycle Therapeutics and within the Lab Support Team. We are looking for a great team player who has excellent organisational skills and someone who can prioritise, communicate, and flex to the task in hand.

You will be involved in both practical scientific work and administrative work to support the company and the different Scientific team’s activities.

Key Responsibilities:

• Providing practical lab support for the Biology and Chemistry teams, acting independently to complete essential support functions:
  • The use and maintenance of ticketing system to liaise directly with scientists to discuss their support requirements.
  • Checking and replenishing reagents and solvents for Chemistry labs.
  • Compressed gases management including liquid Nitrogen.
  • Preparing basic solutions (e.g., buffers, media, and plates).
  • Maintaining Quality Control systems, including tissue culture rooms (Mycoplasma testing).
  • Manual handling and transferring of chemistry waste.
• Provide Technician support when required for sample preparation, which includes:
  • The use and maintenance of electronic lab management systems in liaising directly with scientists to discuss their support requirements.
  • Creating electronic schedules for protein batches using MS Excel and LIMS system.
  • Accurate preparation of protein batches, both solid and in solution, using automated and non-automated methods.
  • Sample inventory management, keeping accurate records using LIMS system and paper-based records.
• Liaising with the logistics coordinator in preparing samples in/out in accordance with standard operating procedure:
  • Preparing samples for delivery to various Contract Research Organisations.
  • Maintaining sample inventory for both shipments to and from external resources.
• Ensuring that the laboratories meet Health and Safety requirements and compliance:
  • By keeping all workspaces clean and tidy.
  • Writing basic Standard Operating Procedures.
  • Maintaining lab records to a high standard.
  • Ensuring all data is captured and archived according to data integrity requirements.
  • Updating and maintaining Bicycle’s Chemical Inventory with relevant data (MSDS) and storage locations.
  • Flushing eye wash stations, water outlets and emergency showers weekly.
  • Weekly removal of clinical waste from the labs.
• Taking a proactive approach to own professional and career development and ensuring compliance with all necessary training:
  • Using Bicycle Tx ‘Training Wheels’.
  • Attending all compulsory work-related training.
• When required ensuring the tasks of the wider team are covered, for example during holiday absences. This will be primarily the tasks of the lab assistant, to include use of glass washing machines, autoclaves, and waste management.

Opportunities available in this role:

• Support Asset Management by:
  • Asset Tagging new equipment and updating the asset management system.
  • Scheduling preventative maintenance and supporting Engineers when onsite.
  • Supporting Service Contract Renewals.
  • Track and trend equipment issues to ensure timely resolution and implement correct actions to reduce future repair requirements.
• Be a member of the ‘Our Green Labs’ team:
  • Be proactive in developing and championing greener ways of working within the team and the wider business.
  • Support Science teams to implement and maintain greener practices, including cold storage maintenance.

Essential:

• A Scientific degree or equivalent.
• Previous Laboratory experience; to include pipetting and sterile techniques.
• Strong understanding of chemical awareness and their associated hazards.
• Competence with the MS Office suite of programmes and ideally a lab-based management system.

Desirable:

• Experience of using a LIMS.
• Proven experience and knowledge of automated compound management and lab-based systems.

Personal Skills and Characteristics:

• Team player with strong motivational skills.
• Excellent organisational skills and ability to prioritise workload.
• Close attention to detail and ability to anticipate and mitigate problems.
• Ability to handle complex information.
• Strong communicator who can work with all levels within the business coupled with a strong desire to get the job done.
• Able to use own initiative and has a positive attitude towards developing efficient ways of working.

• State-of-the-art campus environment with on campus restaurant and Montessori nursery.
• Flexible working environment.
• Competitive reward including annual company bonus.
• Employee recognition schemes.
• 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually.
• Employer contribution to pension (employee does not have to contribute).
• Life assurance cover 4x basic salary.
• Private Medical Insurance, including optical and dental cover.
• Group income protection.
• Employee assistance program.
• Health Cash Plan.
• Access to company subsidized gym membership.
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
• Cycle to work scheme.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.