Laboratory Research Scientist - Tybulewicz Lab

Laboratory Research Scientist - Genetics of Down Syndrome

This is a full-time, 3-year fixed term contract on Crick terms and conditions of employment.

The Tybulewicz group

Genetics of Down Syndrome Laboratory

The lab is studying the genetics of Down Syndrome (DS). Our aim is to identify genes on human chromosome 21 that are required in three copies to cause DS phenotypes and to establish how increased dosage of these genes causes different aspects of DS pathology. A major focus of the group is to understand why congenital heart defects occur in DS. With collaborators, we are also working to understand the neurological aspects of DS. We have generated a series of genetically modified mouse strains with which we can map the location of causative genes and study pathological mechanisms. The lab currently consists of around 12 researchers including PhD students, postdocs, and laboratory research scientists. For more information see the lab website.

Summary

The role of the Laboratory Research Scientist will be to support the postdocs and PhD students working on the genetics of DS, reporting to the Group Leader, Victor Tybulewicz. The postholder will be responsible for the maintenance of multiple genetically altered mouse colonies that are being used to study the genetics of DS and for the supply of experimental animals from these colonies to members of the group and to several collaborators outside the group. The postholder may on occasion need to organise the import and rederivation of novel genetically altered mouse strains. Furthermore, the postholder will be actively involved in studies of congenital heart defects in DS, using high-resolution imaging microscopy and other cutting-edge imaging methods. The postholder may be involved in the generation of novel genetically altered mouse strains. Finally, the postholder will be responsible for general lab management, including ordering for the lab.

Key responsibilities

These include but are not limited to:

• Maintenance of mouse colonies
• Ordering for the lab
• General Lab management
• Supporting research projects of the postdocs and students working on the genetics of Down Syndrome
• Analysis of congenital heart defects in mouse models of Down Syndrome

Key experience and competencies

The post holder should embody and demonstrate our core Crick values: bold, open, and collegial, in addition to the following:

Essential

• BSc (or higher) degree in a relevant subject, e.g. biomedical sciences, genetics
• Experience of management of genetically altered mouse strains
• Knowledge of mouse genetics
• Excellent organisational skills

Desirable

• Experience of mammalian developmental biology
• Experience of image analysis

Find out what benefits the Crick has to offer:

For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits

Equality, Diversity & Inclusion:

We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.

Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.

The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.

Read more on our website:https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion