Global Head Nonclinical Safety, ViiV

Job Description:

Global Head Nonclinical Safety, ViiV from the Company GSK, this latest job vacancy is located in the city London in the country United Kingdom. This job opening is open to job seekers who have a Master Degree.

Job Responsibility:

Site Name: Durham Blackwell Street, GSK HQ, USA - Connecticut - Branford, USA - Pennsylvania - Upper Providence Posted Date: Mar 31 2025

Job Purpose:

The Vice President of Non-Clinical Safety and DMPK is pivotal in safeguarding the safety of ViiV drugs from Discovery through Development and into the post-marketing phase. This role is essential in providing the safety foundation for clinical trials by ensuring the delivery of appropriate toxicology and DMPK packages. These efforts are crucial for understanding exposure and dose targets, clinical monitoring, and forming a critical component of regulatory and other submissions throughout the drug's lifecycle. The VP of Non-Clinical Safety and DMPK is responsible for the strategy and decisions around nonclinical safety, ensuring rigorous oversight within ViiV and in collaboration with GSK. As a core member of the VSLC, this role is integral in delivering a clear and transparent toxicology narrative and risk assessment, thereby significantly contributing to the success and safety of the ViiV portfolio.

Job Responsibilities:

• Design non-clinical safety evaluation strategies: provide comprehensive toxicological interpretations in support of the global development and registration of drug candidates.
• Serve as non-clinical safety and DMPK expert to program and project teams: coordinate non-clinical safety support across all projects in the portfolio from early discovery to marketed projects.
• Leadership and liaison role: facilitate strong partnerships and efficient resource use between ViiV and GSK non-clinical lines to ensure strategic understanding and delivery on ViiV projects.
• Non-clinical review and support: Responsible for non-clinical review forums and nonclinical safety support on technical due diligence.
• Expert advice at key committees: Provide nonclinical safety expertise at ViiV Safety and Labelling Committee and other scientific and management meetings.
• Manage non-clinical delivery for ViiV portfolio: Ensure the delivery of non-clinical data to support the ViiV portfolio and collaborate with GSK staff on nonclinical study delivery, safety, and DMPK issues.
• Provide non-clinical safety and DMPK support to marketed products: Provide non-clinical safety support, review and technical approval for annual reports, literature searches, DSURs, regulatory questions, and more.
• Active member of Early Development Committee: Align non-clinical strategies with business objectives to ensure the successful delivery of the early development pipeline.
• Documentation and representation: Prepare, oversee, review, and present non-clinical safety evaluation information for internal purposes and regulatory authorities.
• Manage ViiV Toxicology and DMPK team: Align strategy and deliverables to identify and progress high-quality candidate compounds, mentor, develop ViiV team and provide matrix management to GSK team members supporting the ViiV portfolio.

Basic Qualifications:

• Life Science Degree with post graduate Masters or PhD.
• Experience of working in the HIV therapeutic area.
• Experience in non-clinical development including post-marketing life cycle management.
• Leadership experience in a matrix environment.
• Knowledge of running non-clinical studies to support various stages of clinical development.
• Effective communication skills.
• Good interpersonal relationship building/maintenance.

If you require an accommodation or other assistance to apply for a job at ViiV, please contact the ViiV Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

ViiV is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.