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An innovative biopharmaceutical company is seeking a passionate Associate Director of Formulation Science to lead the development of cutting-edge medicines. This remote role involves overseeing formulation and process development activities to bring transformative therapies from candidate selection to market launch. You will play a crucial role in collaborating with diverse teams, ensuring compliance with regulatory standards, and driving innovation in drug product manufacturing. Join a mission-driven organization that values teamwork and dedication, where your expertise will contribute to improving patient outcomes through groundbreaking treatments. If you thrive in a dynamic environment and are committed to excellence, this opportunity is perfect for you.
Company Description
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating BT8009, a Bicycle Toxin Conjugate (BTC) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle Radio Conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.
Culture is key and all Bicycle employees actively embrace and role model our company values:
Reporting into the Director of Formulation Science, the Associate Director is a remote role and will be responsible for supporting the formulation and process development activities to take BicycleTx projects from candidate selection through to registration and product launch. A key aspect of the role will be leadership and technical expertise in phase appropriate formulation development, scale up and drug product manufacturing at Contract Development & Manufacturing Organization’s (CDMO’s) through a period of significant growth.
This role requires an ambitious scientist with experience of leading the formulation science elements of integrated CMC programs that deliver high quality, cost effective and robust medicines for patients. Leading formulation development and drug product manufacturing through CDMOs and a track record of innovation are key elements of the role. A broad experience of formulation including product and process design, technology transfer, phase appropriate qualification and process validation is essential.
You will be excellent at stakeholder communication, building effective relationships and managing multiple demands and shifting priorities. You are organized, and excel at developing plans, managing progress, and delivering results. This position will collaborate with other members of CMC, Quality Assurance, Regulatory Affairs, Commercial, and Finance teams to enable product development.
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Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.