Targeting the 2C protein of Enteroviruses to develop novel antivirals

This PhD study is part of an ANR project entitled ‘Fluox2C’, involving 3 laboratories (ICR CNRS-Aix-Marseille University, UVE IRD-INSERM-Aix-Marseille University and ICOA CNRS-Orléans University).

In recent years, several Enteroviruses have emerged as pathogens of increasing public health concern and against which no licensed antiviral therapy exists. In such a context, the objective of the ‘Fluox2C’ project is to develop potent broad-spectrum antivirals to treat Enterovirus infections and severe related disorders. This work will lay the foundation for a new antiviral strategy targeting specifically the 2C protein of Enterovirus, a critical protein in viral replication, through the design and the synthesis of novel antivirals with original modes of action.