PostDoc Toxicologue Recherche NGRA

Sophia Antipolis Postulez maintenant

Position Description

In the context of the new toxicity testing paradigm based on more (animal and human) cell-based assays and a comprehensive mechanistic understanding of cause-consequence relationships for adverse effects induced by (agro)chemicals, your role will be to develop, implement and apply new alternative methodologies (NAMs):

• Design, develop, and implement new in vitro methodologies and complex in vitro assays to predict potential in vivo adverse effects.
• Establish toxicology and business relevant medium to high throughput in vitro test systems able to mimic the in vivo situation in order to quantify the risk in human beings.
• Utilize advanced technologies to study biological and molecular processes: e.g., apply relevant biomarkers and use image analysis for quantification, perform biological assays to monitor cell behavior and function.

Qualifications

• Biologist or Scientist with a PhD degree related to tissue engineering, biotechnology, systems biology, toxicology, or related disciplines.
• You have strong expertise in cellular models and morphological-molecular profiling. Proven hands-on experience with a variety of cell-based models and experience with different readouts along with state-of-the-art imaging methods and molecular biology (immunostaining, confocal imaging, qPCR, flow cytometry, toxicogenomics etc.) will be looked at. Experience in toxicity assays with hepatocytes/neuron and/or experimental characterization and (ideally, mathematically description) of dose/concentration toxicity pathways would be a plus.

Apply