Guillaume Gines, PhD

Molecular programming and sequencing readout for accurate and multiplexed microRNA quantification.

Mission

Our team is looking for a talented and motivated postdoc to work on microRNA detection technologies. The postdoctoral position, funded by an ERC starting grant (MoP-MiP), is open.

I am Guillaume, CNRS researcher at ESPCI Paris in the Laboratory Gulliver located in Paris. My research interests are centered around DNA nanotechnologies and molecular programming, from their fundamental demonstrations to applications in diagnostics and biotechnology.

Research Overview

Out in Nature Nanotechnology, our work leverages a versatile molecular circuit with droplet microfluidics for the detection, quantification, and analysis of enzymes at the single molecule level. The article can be accessed by following this link: https://rdcu.be/dzDGz.

Development of a multimodal and multiplex cancer biomarker quantification method. A 2-year postdoc position is open at ESPCI Paris to work on a collaborative project between the Laboratory Gulliver (ESPCI), the laboratory MEPPOT (University of Paris).

Background

MicroRNAs are short endogenous RNA strands that finely tune gene expression. Countless articles have reported a link between the dysregulation of microRNA expressions and diseases including cancer or neurodegenerative diseases, among others. These disease signatures often involve more than one microRNA.

MicroRNAs are foreseen as promising biomarkers for diagnosis, prognosis, and follow-up of cancer diseases. The objective of this work is to propose a novel technology for the reliable and sensitive detection of these biomarkers.