Post-doctoral research position in the team “Transcriptional regulation of neural and immune de[...]

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Post-doctoral Research Position

Team: Transcriptional regulation of neural and immune development

Client:

IGBMC

Location:

Strasbourg

Job Category:

Other

EU Work Permit Required:

Yes

Job Reference:

0984be18eeaf

Job Views:

21

Posted:

22.01.2025

Expiry Date:

08.03.2025

Job Description:

The team Transcriptional regulation of neural and immune development at the IGBMC (Institut de génétique et de biologie moléculaire et cellulaire) in Strasbourg is recruiting a postdoctoral researcher to study the cross-talk between macrophages and the intestine epithelium during enteric infection using the model organism Drosophila melanogaster. The project is funded by an ANR and is carried out in close collaboration with the team of Dr. Dominique Ferrandon (IBMC, Strasbourg).

The recruited researcher will integrate into the team headed by Dr. Angela Giangrande and will be supervised by Dr. Pierre Cattenoz. The IGBMC is a joint research unit between CNRS, INSERM, and the University of Strasbourg, comprising around 600 staff scientists. The Institute is located in Illkirch, adjacent to Strasbourg, and hosts multiple platforms providing access to state-of-the-art technologies, including high-throughput techniques (Genomeast) and microscopy (ICI). The working language of the laboratory is English.

The goal of the project is to decipher the mechanisms regulating intestinal resilience after enteric challenges in adult Drosophila. Data generated by our collaborator showed that the intestinal epithelium undergoes drastic thinning upon cytotoxic bacterial infection and recovers quickly after the removal of the bacteria. This phenomenon is conserved in mammals. The thinning of the epithelium is regulated in part by macrophages. Our laboratory has identified different subgroups of macrophages in Drosophila displaying specific properties, and our current challenge is to identify the macrophage subgroup(s) interacting with the intestine and the molecular pathways involved in the process. The recruited postdoc will use single-cell sequencing and spatial transcriptomics, as well as the extensive genetic toolbox available in Drosophila, to characterize the signaling pathways involved in the intestine/macrophage interaction leading to the thinning of the epithelium.

The post-doctoral contract is for 2 years, extendable, and will start from October 2024. Potential applicants should submit their applications to [insert contact]. For any questions, do not hesitate to contact Angela Giangrande ([insert contact]) or Pierre Cattenoz ([insert contact]).

Missions

The recruited postdoc should have a strong interest in innate immunity and preferably extensive experience in molecular biology and next-generation sequencing. Previous experience in Drosophila and confocal microscopy is recommended but not required.