Post-Doc position in Molecular Biology Droplet-based microfluidics and RNA expression CBI - ESP[...]

Post-Doc Position in Molecular Biology: Droplet-based Microfluidics and RNA Expression

Location: CBI - ESPCI Paris LBC Team - Prof. Andrew Griffiths (F/H)
ESPCI Paris - PSL
10 Rue Vauquelin 75005 Paris

About ESPCI Paris - PSL

ESPCI Paris - PSL is a major institution of higher education (a French "Grande École d’ingénieurs"), an internationally renowned research center (6 Nobel Prizes), and a fertile ground of innovation for industry (3 start-ups created/year). ESPCI is a highly multidisciplinary environment with teaching and research in physics, chemistry, and biology.

About Prof. Andrew Griffiths’ Lab

The research activities of the Laboratory of Biochemistry team at ESPCI Paris-PSL, directed by Prof. Andrew GRIFFITHS, are based around droplet-based microfluidics, a powerful new ultrahigh-throughput system in which reaction volumes can be miniaturized by up to a million-fold compared to conventional assays in microtitre plates. This opens up exciting prospects for the development of extremely innovative systems with many applications in the Life Sciences. The successful candidate will join a highly multidisciplinary team, with experience spanning biology, chemistry, and physics.

Mission

The dynamic nature of chromatin and transcriptional features are expected to participate in tumor evolution, particularly in the context of response to cancer treatment and acquisition of resistance. In triple-negative breast cancer (TNBC), we have recently revealed the heterogeneity of chromatin states in patient-derived xenografts models of acquired resistance to Capecitabine.

The Post-Doc will work on the development of a droplet-based microfluidics approach for the simultaneous profiling of histone modifications and RNA expression on the very same cell.

Requirements

We are seeking a highly motivated Post-Doc with strong experience in molecular biology (scChIP-seq and RNA-seq) or a related field. Experience in microfluidics, cell biology, and bioinformatics is highly appreciated.

Flexibility, autonomy, the ability to work in a highly multidisciplinary team, and good interpersonal skills are essential.

Application Process:
Address your applications (CV + cover letter) by email to: