Two (2) Post-Doc positions in Molecular Biology Droplet-based microfluidics / barcoded DNA / an[...]

Two (2) Post-Doc Positions in Molecular Biology Droplet-based Microfluidics / Barcoded DNA / Antibody Discovery (F/H)

ESPCI Paris-PSL

ESPCI Paris-PSL is a major institution of higher education (a French "Grande École d’ingénieurs"), an internationally renowned research center (6 Nobel Prizes), and a fertile ground of innovation for industry (3 start-ups created/year). ESPCI is a highly multidisciplinary environment with teaching and research in physics, chemistry, and biology.

Prof. Andrew Griffiths’ Lab

The research activities of the Laboratory of Biochemistry team at ESPCI Paris-PSL, directed by Prof. Andrew Griffiths, are based around droplet-based microfluidics, a powerful new ultrahigh-throughput system in which reaction volumes can be miniaturized by up to a million-fold compared to conventional assays in microtitre plates. This opens up exciting prospects for the development of extremely innovative systems with many applications in the Life Sciences. The successful candidate will join a highly multidisciplinary team, with experience spanning biology, chemistry, and physics.

Mission

Project

Over the last decade, antibody-based therapies have made significant impacts on several diseases. Increasing efforts are being made by researchers and big pharma to find novel high-impact antibodies.

Two post-docs will collaborate together and work on the characterization of millions of individual antibody-secreting cells using a droplet-based microfluidic platform combined with DNA barcode and next-generation sequencing. The project (CelliGO) is in collaboration with the company HiFiBiO, a spin-off from ESPCI, Harvard University, and the Broad Institute.

Requirements

We are seeking two highly motivated Post-Docs with strong experience in molecular biology or a related field. The Post-Docs should be interested in learning how to use microfluidic systems. Flexibility, autonomy, the ability to work in a highly multidisciplinary team, and good interpersonal skills are essential.

Address your applications (CV + cover letter) by email to: