Bioinformatician - Postdoc/IR (M/F)

DNA replication/repair Genome Stability NGS Nanopore sequencing High-throughput single-molecule imaging Bionano

Description

The hosting structure
Institut Curie Research Center
Institut Curie is a major player in the research and fight against cancer. It consists of a hospital group and a Research Center of more than 1000 employees with a strong international representativeness. The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Context
Laboratory
We are seeking a motivated and productive bioinformatician (M/F) to join our team “Replication Program and Genome Instability” (Team CHEN) at the Institut Curie, Paris, France. The team focuses on using cutting-edge high-throughput genomic approaches and genome-wide data analyses to study the spatio-temporal replication program of the human genome and how replication stress impacts on genome stability in normal and cancer cells, in population as well as at single molecule/cell level.

The project
The successful candidate (M/F) will join our interdisciplinary effort to uncover the mechanisms safeguarding genome stability during DNA replication and repair. DNA double-strand breaks (DSBs) and replication stress are critical threats to genome integrity, linked to diseases like cancer and neurological disorders. Our projects integrate cutting-edge high-throughput single-molecule imaging (e.g. Bionano) and sequencing (e.g. Nanopore) with computational modeling and bioinformatics to study these processes at unprecedented resolution. The interplay between DNA replication and repair is crucial for maintaining genome integrity. By leveraging innovative technologies and collaborating with leading experts, we aim to unravel how replication stress and DNA repair intersect to maintain genome stability. This interdisciplinary effort is expected to yield transformative insights into the molecular underpinnings of diseases like cancer and neurodegenerative disorders.

Candidate Profile
Training and Skills required:
- Applicant (M/F) should hold, or in the process of completing, a PhD degree in biology, bioinformatics, or related areas.
- Scientific skills:
o Solid computational/statistical skills,
o Solid background in molecule/cellular biology,
o Strong interest in genome biology.
- Experience:
o High-throughput sequencing data analysis,
o 3rd generation sequencing (Nanopore sequencing),
o Lineage tracing analysis is a plus,
o High-throughput imaging analysis is a plus.
- Language skills: very good English level (working language) and communication skills.

Contract information
Type of contract: Fixed-term contract.
Starting date: January 2025
Duration: 2 years
Working time: full time
Remuneration: according to the current grids
Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
Location of the position: Paris, 5eme

Contact
Please send your CV, letter of motivation and 3 references to job-ref-p2l94ee0gh@emploi.beetween.com. CVs to be processed on the go, therefore the position could be filled before the deadline for applications.

Institut Curie is an inclusive, equal opportunity employer and is dedicated to the highest standards of research integrity.