Bioinformatician (IE/IR) Institut Curie Paris

CDD·IE·18 mois Bac+5 / Master Centre de recherche de l'Institut Curie·Paris (France) according to the current grids

cancer single-cell omics transcriptomics epigenomics plasticity reprogramming

Description

The hosting structure

The Institut Curie Research Center
Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital Group and a Research Center of more than 1000 employees with a strong international representativeness.
The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Laboratory
In an extremely dynamic environment, Isabelle Janoueix-Lerosey’s team is working on the biology of pediatric cancers, and particularly of Neuroblastoma. Our team is covering diverse aspects of fundamental research from the embryonic initiation of tumor development, to the mechanisms of tumor progression and metastases, going to the study of resistance to treatments, also by integrating tumor-microenvironment interactions.
To address all our challenging questions, we generate and explore a large quantity of omics data from high-quality technological platforms from the Institute. Based on innovative technologies, we produce bulk and single-cell data including mainly transcriptomics (RNA-seq, scRNAseq, spatial transcriptomics) and epigenomics (ChIP-seq, ATAC-seq, scATAC-seq) or both (MultiOme).

Missions
The candidate will be in charge of:

1. Performing end-to-end data analysis of a wide range of epigenomic sequencing data generated by our team at bulk and single cell level (ChIP-seq, ATAC-seq data and scATAC-seq)
2. Integrating these results with other omics data (RNA-seq, scRNA-seq)
3. Using and/or developing methods and strategies to explore the data in close collaboration with biologists
4. Monitoring technological advancements in relevant bioinformatics analysis methods
5. Presenting in team meetings.

The candidate will be supervised by the researchers and the permanent bioinformatic scientist of the team. She/he will benefit from daily exchanges with the PhD students and postdocs also analyzing their data, as well as with the wet lab scientists of our team. Additionally, the candidate will have the opportunity to interact with the broader bioinformatics community at Institut Curie through Curie Bioinformatics Hub.

Candidate profile

Training and experience required
- Master degree in Bioinformatics or related fields with at least 2 years experience
- or PhD in Data Science, Bioinformatics or related fields.

Skills required
- Solid skills in handling NGS datasets
- Solid experience in bash and R/python (other programming languages are a plus)
- Experience with working in an Unix environment
- Experience with working on a computer cluster would be a plus
- Good experience in statistics (hypothesis testing, normalization, differential analysis…)
- Good working knowledge in epigenomics and/or cancer biology would be a plus
- Highly motivated and able to collaborate within the team and to work with biologists and bioinformaticians
- Good skills in written and oral English would be a plus (knowing French is not necessary if the candidate has a good level in English)

Contract information

Type of contract: Fixed-term contract for IE/IR
Starting date: March 2025
Duration: 18 months
Working time: full time
Remuneration: according to the current grids
Benefits: Collective catering, reimbursement of transportation fees up to 70%, RTT days
Location of the position: Centre de Recherche Paris, Bâtiment Trouillet-Rossignol, 26 rue d’Ulm, 75005 Paris

Contact

Please send your CV, letter of motivation and 2 references to Isabelle Janoueix-Lerosey : isabelle.janoueix@curie.fr