Postdoctoral Fellow - Dayton Group - Cancer-GENOXIC ⟶

Postdoctoral Fellow - Dayton Group - Cancer-GENOXIC

Apply remote type Campus based locations Barcelona time type Full time posted on Posted 9 Days Ago job requisition id JR621

Your role

We are looking for a postdoctoral researcher to work on a project using human organoid models to understand how hypoxia, nicotine, and genetic perturbations influence the plasticity of pulmonary neuroendocrine cells and their susceptibility to cancer. We are particularly interested in exploring how chromatin dynamics impact the response to injury, plasticity, and cancer initiation.

Ultimately, we aim to generate genetically engineered human organoid models of neuroendocrine cancer. The project will involve international collaborations with clinicians and environmental epidemiologists as well as the generation and analysis of single cell -omics datasets. Many details of the project can be tailored to fit the candidate’s particular expertise and interests. This specific position is for a 3-year appointment with the possibility and expectation for renewal.

The successful candidate will be intrinsically motivated, and will lead their own project, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD and Masters students in their research. We are looking for a postdoctoral researcher who is not only scientifically curious and driven but also values teamwork, constructive feedback, and interdisciplinary collaboration. This position is ideal for someone who enjoys generating new ideas and contributing to project design while maintaining a collaborative approach.

Importantly, the candidate will contribute to shaping the environment and research of a young and growing research team.

You have

• PhD and/or MD or equivalent doctoral degree
• demonstration of expertise in the form of published paper(s) or preprints
• strong practical skills in primary cell culture
• strong molecular biology skillset in chromatin dynamics and epigenetics
• demonstrated expertise in cancer biology, particularly in the context of chromatin regulation and cellular plasticity
• hands-on experience with CRISPR/Cas9-based genetic perturbation, including pooled or arrayed screening approaches
• ability to prioritize, see the big picture, and nevertheless focus on details
• strong problem-solving skills, ability to troubleshoot experiments independently, and a critical mindset towards data interpretation
• ability to work independently, quickly set up effective networks and working relationships
• ability to adapt to new techniques, integrate feedback, and collaborate effectively in a multidisciplinary team
• excellent verbal and written communication skills in English

You may also have

• experience analyzing and integrating single-cell multi-omics datasets (e.g., single-cell RNA-seq, ATAC-seq, or spatial transcriptomics) is a plus.
• experience in 3D organoid models
• skills in advanced microscopy techniques is an asset

Don’t meet every single requirement? We are dedicated to building a diverse, inclusive and authentic workplace, so if you’re excited about this role but your past experience doesn’t align perfectly with every qualification in the job description, we encourage you to apply anyways.

What else you need to know

• International applicants: We recruit internationally and successful candidates are offered visa exemptions. Read more on our page for international applicants.
• Diversity and inclusion: At EMBL, we strongly believe that inclusive and diverse teams benefit from higher levels of innovation and creative thought. We encourage applications from women, LGBTQ+ & individuals from all nationalities.
• Job location: All our fellowships are based on-site (for at least part of each week). If you are living overseas, you will receive a generous relocation package to support you.
• EMBL is a signatory of DORA. Find out how we apply DORA principles to our recruitment and performance assessment processes here.
• How to apply: To apply please submit a cover letter and a CV through our online system. Applications will close at 23:59 CET on the date shown below. We aim to provide a response within two weeks after the closing date.

Closing Date: 29/04/2025

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