Senior Scientist/Principle Scientist– Cell Biology and Immunology

Senior Scientist/Principle Scientist– Cell Biology and Immunology

• Full-time

From the very beginning, we have been focusing on the science. We came together as a team of experts, committed to quality, driven by excellence, and dedicated to experimentation. Though we faced many challenges, we remained fearless in our research and rigorous in our thinking, pushing ourselves to work harder. However, what affected us the most was the enormous burden patients bear and the difficulties they face, which drove us to think about what’s next.

We believe it is time to accelerate and expand that transformation. At Legend Biotech, we are excited to bring clinical trials to patients in our pursuit of a cure. While we are focusing on CAR-T in multiple myeloma, we firmly believe the prospects of cellular therapy stretch beyond just one disease or indication. The spark of hope is lit. At Legend Biotech, we are using that hope to ignite the future of CAR-T cell therapy.

Role Overview:

Legend Biotech is a clinical stage biopharmaceutical company focused on the discovery and development of novel cell therapies for oncology, immunology, and infectious disease indications. We are currently seeking talented and motivated individuals to join the group of Cell Biology and Immunology in the R&D Department located in Piscataway, New Jersey. The successful candidate should possess extensive knowledge and hands-on experience in oncology, cell biology, and immunology, particularly in TCR-T/CAR-T cell biology. The candidate will contribute to the effort for developing T cell therapy platforms, building and optimizing cell-based immunoassays to characterize and assess TCR-T/CAR-T cell functions. Experience with TCR-T/CAR-T cells is preferred. As major contributors to pipeline development, candidates need to demonstrate the ability to plan, design, execute complicated experiments, and deliver scientific results in a cross-functional environment. This position also requires supervision and management skills.

Major Responsibilities:

• Independently plan, design, and execute experiments to assess the in-vitro functions of TCR-T/CAR-T cells.
• Develop T cell therapy platforms and optimize cell-based immunoassays, including ex-vivo antigen-specific T cell isolation and expansion, multi-color flow cytometry, ELISA, ELISPOT, and cytotoxic assays.
• Deliver scientific results at internal and external meetings.
• Supervise associate scientists for routine laboratory work.
• Assist group leader with general laboratory management.
• Serve as major contributors to pipeline development.

Education:

• PhD in cell biology/immunology.

Experience:

• >3 years’ post-graduate experience in human T-cell biology and immunology.
• Extensive hands-on experience in TCR-T/CAR-T cell for cancer immunotherapy.
• >1 year of supervisory experience.

Key Capabilities, Knowledge, and Skills:

• Extensive knowledge and hands-on experience in TCR-T/CAR-T field. Experience in immune-oncology preferred.
• Expertise in cell biology and immune cell profiling; extensive experience in multi-color flow cytometry.
• Hands-on experience and troubleshooting proficiency with immune cell isolation from peripheral blood and leukopak, expansion, and cell-based immunoassays.
• Experience with dendritic cell culture and DC-T cell coculture for antigen-specific T cell.
• Experience with lentivirus/retrovirus preparation, titration, and T cell transduction.
• Experience in CRISPR/CAS-9 for gene knock-out and knock-in.
• Track record of scientific publications and accomplishments.
• Demonstrated ability in presenting scientific results.
• Excellent oral and written communication skills.
• A team player who can work efficiently as an individual.

Legend Biotech USA Inc. is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

Legend Biotech USA Inc. maintains a drug-free workplace.