R&D Laboratory Technician

Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines. Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion’s clinical portfolio includes: FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial; FPI-2059, a small molecule targeting neurotensin receptor 1 (NTSR1), currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. In addition, Fusion is pursuing combination programs between RCs and DNA Damage Response Inhibitors (DDRis) and immune-oncology agents. Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radiopharmaceutical manufacturing facility to meet supply demand for Fusion's growing pipeline of RCs.

Fusion is seeking outstanding applicants for a R&D Laboratory Technician to support a broad range of preclinical drug development activities. This position is lab-based, and located in Hamilton, Ontario, Canada.

Responsibilities:

• Perform and report on in vitro bioassays and related molecular and biochemical assays.
• Perform mammalian cell culture in support of biology group activities.
• Establish tumour xenografts, and administer test articles to rodents by various routes including injection and oral gavage.
• Perform histological assays on tissues (e.g. tissue embedding, processing, sectioning, and immunohistochemistry).
• Conduct and report on therapeutic efficacy and biodistribution studies of radiopharmaceuticals using rodent models of cancer (or other disease indications of interest).
• Document experimental procedures and results in an electronic notebook system
• Maintain laboratory records (SOPs, SDS, chemical, radioisotope, biohazard, cell bank).
• Other duties as required.

Qualifications:

• Bachelor’s degree in Science, Health Sciences, biological engineering, or a related field is required.
• 2-5 years of work experience with mammalian cell culture, experience with general biochemical methods (e.g., protein quantification, ELISA, SDS-PAGE and immunoblotting, UV/VIS spectroscopy) and cell biological methods (eg. flow cytometry, immunohistochemistry).
• Experience with histological techniques (handling/processing of FFPE and fresh frozen tissues, along with IHC and IHC-F staining techniques) is an asset.
• Experience with lab animal experimentation and handling (tumor inoculations, rodent test article administration by intravenous, intraperitoneal and gavage methods, tissue dissection) is preferred.
• Highly organized with proven ability to work independently with strong communication skills.
• Ability to work effectively in a multi-disciplinary team and communicate with colleagues at all levels.
• Experience with the safe handling of radioactive and biohazardous materials/waste.
• Willingness to take on new tasks and responsibilities as required.
• Ability to thrive in a fast-paced, dynamic environment and manage multiple priorities simultaneously.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.