Principal Scientist Medicinal Chemistry

View more categories View less categories Discipline Clinical Research Hours Full Time Contract Type Permanent Experience Level Experienced (non-manager)

Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Job Description

The Principal Scientist will design and synthesize novel chemical constructs as potential new RPT therapies for cancer treatments. This position will require a highly motivated and experienced medicinal chemist with strong synthetic organic and/or peptide chemistry skills. The role will offer an opportunity to work as functional lead on multiple projects ranging from target selection through candidate nomination stages and can be expected to lead early-stage projects in an interdisciplinary setting. The role is highly technical and will need a person who enjoys leading from the bench with high productivity and data analysis skills and a comfort level in working under tight timelines. The role requires an ability and willingness to manage both internal and external chemistry personnel.

Job Responsibilities

Essential duties and responsibilities include the following. Other duties may be assigned.

• Design and synthesize small molecule/peptide compounds in support of SAR campaigns for pipeline projects.
• Lead SAR efforts on assigned projects, design and synthesize key target molecules to assess chemical/biological hypothesis.
• Work in close collaboration with interdisciplinary teams to provide functional chemistry leadership to guide programs through lead identification/optimization phases.
• Work closely with biology, DMPK, imaging and in vitro/vivo teams to ensure that target compounds are generated in a timely manner to support the screening funnel.
• Supervise the work of junior scientists and ensure experimental rigor and high quality.
• Regularly present research findings and project updates to interdisciplinary teams.
• Keep abreast of the literature in the field of RPTs, identify novel concepts and ideas to help advance the state of art in RPT field.
• Participate in intellectual property filings and the preparation of publications and presentations.
• Identify external partners, KOLs, outside expertise that will help advance the pipeline.
• Serve as the scientific lead for external partnerships, collaborations and lead scientific projects through outsourcing if needed.
• Adhere rigorously to safety guidelines, regulatory standards and company policies and ensure a safe working environment.

Education and Experience

• PhD in synthetic organic, peptide or medicinal chemistry with 5+ years of experience or MS 10+ years in pharmaceutical/biotech R&D environments demonstrating successful accomplishments and progressive leadership and broadening responsibilities.
• Experience in working on targeted cancer therapy modalities such as RPTs, ADCs, PDCs is highly desirable.

Skills and Qualifications

• Experience in leading small molecule/peptide projects from screening hit to development candidate.
• Demonstrated ability to supervise and effectively guide the work of junior scientists and has managed external chemistry resources.
• Strong interpersonal, organizational and communication skills and ability to motivate and drive productivity in small company environments. Prior experience as a chemistry leader or functional leader on interdisciplinary team is critical.
• Well versed in modern synthetic organic/peptide/med chem principles and demonstrated track record of high productivity and achievements in the lab.
• High scientific curiosity and a learning mindset coupled with strong technical problem-solving skills and strong understanding of the concepts of drug design, SAR analysis, ADME/PK is important.
• The ability to share data and collaborate with cross functional team members is critical as is the ability to effectively interpret data and plan experiments without supervision.
• Excellent written and oral communication and presentation skills and ability to work in a fast-paced, dynamic, and collaborative environment.

Physical Demands

While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 30 pounds. Specific vision abilities required by this job include close vision and distance vision.

This is a position that requires working in a laboratory environment, protective clothing, gloves, and safety glasses are required while working in a laboratory environment.

Work Environment

The noise level in the work environment is usually moderate.

The starting compensation for this job is a range from $148,000 - $179,300 plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients' lives through science, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/.

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