Principal Scientist- Cancer Biology

Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Job Description

The role offers an opportunity to take a leadership role in defining and implementing the biology strategy for the pipeline projects from target selection through candidate nomination stages. The ideal candidate will be an experienced, accomplished biologist with outstanding interpersonal and communication skills. The role will work closely with the leadership team to develop and execute overall project strategy, including forecasting resource needs and ensuring deliverables are met under tight timelines. The position will require an ability to work effectively in interdisciplinary team settings and is expected to supervise and guide junior team members. This role is expected to provide technical leadership in the lab as pertains to developing, validating, and executing in vitro assays, developing oncology models to support the project needs. The role requires an ability and willingness to work with radioactive isotopes.

Job Responsibilities

Essential duties and responsibilities include the following. Other duties may be assigned.

1. Utilize a deep understanding of cancer biology and oncology drug development to lead the efforts on target selection and initiation of new RPT projects.
2. In partnership with a cross-functional team leader, provide strategic and operational leadership for project teams on specific targets.
3. Work in close collaboration with interdisciplinary teams to provide functional biology leadership to guide programs through lead identification/optimization phases.
4. Help with the generation of preclinical GLP/non-GLP data packages in support of regulatory submissions and clinical development.
5. Help with the formulation of a translational biology plan to support the clinical development strategy.
6. Author/review study reports and regulatory documentation, scientific presentations, and publications, and manage external research collaborations.
7. Assess scientific and research needs for a project and engage with external partners, KOLs, and set up external partnerships as needed.
8. Serve as the scientific lead for external partnerships, collaborations, and lead scientific projects through outsourcing if needed.
9. Drive innovation and novel approaches in radiopharmaceutical research and development, contributing to the company's competitive edge in the industry.
10. Effectively manage internal, external resources, and budgets in support of corporate goals.

Education and Experience

• PhD in cancer biology, cell biology, pharmacology, or a related field and a deep understanding of cancer biology and experience working in oncology drug development is ideal.
• 7+ years of experience in pharmaceutical/biotech R&D environments demonstrating successful accomplishments and progressive leadership and broadening responsibilities.
• Experience in working on targeted cancer therapy modalities such as RPTs, ADCs, PDCs is highly desirable.

Skills

• Excellent written and oral communication and presentation skills and ability to work in a fast-paced, dynamic, and collaborative environment.
• Strong interpersonal, organizational, and communication skills and ability to motivate and drive productivity in small company environments. Prior experience as a project leader or functional leader on interdisciplinary teams is critical.
• Strong expertise with in vitro, cell-based assay development and optimization and proficiency with cell culture, molecular biology techniques, ELISA, flow cytometry, western blot, qPCR, single-cell cloning, immunohistochemistry, and related protocols.
• Familiarity with ADME/PK concepts and drug development process and interfacing with regulatory teams would be desirable.
• Familiarity with the development and use of in vivo oncology models is critical as is the ability to design and supervise appropriately controlled in vivo experiments.
• Ability to effectively partner with Clinical, regulatory, CMC, and chemistry/DMPK teams and successfully lead interdisciplinary scientific teams and experience in mentoring and managing the work of junior scientists.
• Ability to work with radioisotopes with strict adherence to radiation safety protocols.
• Ability to successfully establish and manage external collaborations including CROs and academic and industrial partnerships.

Physical Demands

While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 25 pounds. Specific vision abilities required by this job include close vision and distance vision.

This is a position that requires working in a laboratory environment; protective clothing, gloves, and safety glasses are required while working in a laboratory environment with radioactive materials.

Work Environment

The noise level in the work environment is usually moderate.

The starting compensation for this job is a range from $148,000 - $179,300 plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental, and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection, and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder, and pet care resources. Other perks like tuition reimbursement and a recognition program.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients' lives through science, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion, and integrity bring out the highest potential of each of our colleagues.