Associate Research Scientist II

From the very beginning, we have been focusing on the science. We came together as a team of experts, committed to quality, driven by excellence, and dedicated to experimentation. Though we faced many challenges, we remained fearless in our research and rigorous in our thinking, pushing ourselves to work harder. However, what affected us the most was the enormous burden patients bear and the difficulties they face, which drove us to think about what’s next.

We believe it is time to accelerate and expand that transformation. At Legend Biotech, we are excited to bring clinical trials to patients in our pursuit of a cure. While we are focusing on CAR-T in multiple myeloma, we firmly believe the prospects of cellular therapy stretch beyond just one disease or indication. The spark of hope is lit. At Legend Biotech, we are using that hope to ignite the future of CAR-T cell therapy.

Job Description

Role Overview:

Legend Biotech is a clinical stage biopharmaceutical company focused on the discovery and development of novel cell therapies for oncology, immunology and infectious disease indications. We are currently seeking a talented and motivated candidate to join the R&D cell biology and immunology lab at our US site. The successful candidate will contribute to the company’s efforts to develop next-generation cell therapies in solid tumor malignancies. The successful candidate will have a strong molecular biology, cell biology, and immunology background, and is expected to work in a collaborative cross-functional team environment, perform experiments, organize and analyze results, communicate effectively, and present findings in team meetings.

Major Responsibilities:

• Assist in developing T cell therapy platform, perform cell-based immunoassays, including ex-vivo antigen specific T cell isolation and expansion, viral-vector based introduction of TCRs / CARs into human T cells, multi-color flow cytometry, ELISA, and ELISPOT assays.
• Culture and characterize genetically modified human T cells and tumor cells including gene expression and cell functionalities testing.
• Plan and execute in vitro functional assays with T cells according to project goals and timelines.
• Effectively communicate plans and results in both oral and written form.
• Ability to work in a highly dynamic collaborative team environment.
• Other duties as assigned.

Qualifications

Education:

• B.S. or M.S. in biomedical science field or cell biology and immunology.

Experience:

• 5 years with B.S. or 2-5 years with M.S. Industry/academic experience in Immunology/Cell Biology, preferably Immunotherapy.

Key Capabilities, Knowledge, and Skills:

• Experience with multi-color flow cytometry and data analysis (FACSDiva, FlowJo) required.
• Experience with primary T cell-based assays preferred.
• Excellent mammalian cell/tissue culture and sterile technique required.
• Strong organizational skills and record keeping.
• Self-motivated and willing to accept temporary responsibilities outside of initial job description.
• Comfortable in a fast-paced environment and able to adjust workload based upon changing priorities.
• Excellent interpersonal, verbal, and written communication skills are essential in this collaborative work environment.