Principal ScientistDirector Chemical Biology

About You

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.

Qualifications & Nice-To-Haves

1. PhD in Chemical Biology, Medicinal Chemistry, Pharmacology, or related field.
2. Experiencing leading and managing highly effective teams in the industry.
3. Deep understanding of small-molecule drug discovery and its relationship to human disease.
4. Strong experience with:
   • Hit finding and hit-to-lead studies
   • HTS and phenotypic assay development and screening
   • Small molecule binding affinity assays
   • PPI techniques, e.g., BRET, APEX/BioID, AlphaScreen
5. Proficiency in:
   • Platform development
   • Compound management
   • Disease model development
   • Biochemical assay development
6. Nice to have:
   • Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc.
   • Familiarity or experience with PROTAC/next-gen IPM technologies
   • Biophysical screening techniques such as SPR or fluorescence anisotropy
   • DEL experience
   • Experience with med-chem optimizations: SAR, PK/PD, etc.
   • Computational drug discovery experience
   • Prior experience on teams that have successfully advanced research to the clinic

Benefits

1. Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
2. Top tier medical, dental, and vision coverage + One Medical membership.
3. 401(k) retirement plans.
4. Education and health/fitness incentive programs.
5. Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.
6. Reading budget! We will buy you books.
7. Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.